<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Xia, J.</style></author><author><style face="normal" font="default" size="100%">Sedransk, N.</style></author><author><style face="normal" font="default" size="100%">Feng, X.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Variance Component Analysis of a Multi-Site Study of Multiple Reaction Monitoring Measurements of Peptides and Proteins in Human Plasma</style></title><secondary-title><style face="normal" font="default" size="100%">PLoS1</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">analysis of Variance</style></keyword><keyword><style  face="normal" font="default" size="100%">blood plasma</style></keyword><keyword><style  face="normal" font="default" size="100%">experimental design</style></keyword><keyword><style  face="normal" font="default" size="100%">Instrument calibration</style></keyword><keyword><style  face="normal" font="default" size="100%">linear regression analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">peptides</style></keyword><keyword><style  face="normal" font="default" size="100%">plasma proteins</style></keyword><keyword><style  face="normal" font="default" size="100%">proteomic databases</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year></dates><number><style face="normal" font="default" size="100%">1</style></number><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">e14590</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;In the Addona et al. paper (Nature Biotechnology 2009), a large-scale multi-site study was performed to quantify Multiple Reaction Monitoring (MRM) measurements of proteins spiked in human plasma. The unlabeled signature peptides derived from the seven target proteins were measured at nine different concentration levels, and their isotopic counterparts were served as the internal standards.&lt;/p&gt;
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