<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Remlinger KS</style></author><author><style face="normal" font="default" size="100%">Hughes-Oliver JM</style></author><author><style face="normal" font="default" size="100%">Young SS</style></author><author><style face="normal" font="default" size="100%">Lam RL</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Statistical design of pools using optimal coverage and minimal collision</style></title><secondary-title><style face="normal" font="default" size="100%">Technom</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Pharmaceutical industry</style></keyword><keyword><style  face="normal" font="default" size="100%">Pooled data</style></keyword><keyword><style  face="normal" font="default" size="100%">Pooling</style></keyword><keyword><style  face="normal" font="default" size="100%">Screening</style></keyword><keyword><style  face="normal" font="default" size="100%">Throughput</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2006</style></year></dates><volume><style face="normal" font="default" size="100%">48</style></volume><pages><style face="normal" font="default" size="100%">133-143</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The screening of large chemical libraries to identify new compounds can be simplified by testing compounds in pools. Two criteria for designing pools are considered: optimal coverage of the chemical space and minimal collision between compounds. Four pooling designs are applied to a public database and evaluated by determining how well the design criteria are met and whether the methods are able to find diverse active compounds. While one pool was outstanding, all designed pools outperformed randomly designed pools.&lt;/p&gt;
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