<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Susan Abbatiello</style></author><author><style face="normal" font="default" size="100%">Birgit Schilling</style></author><author><style face="normal" font="default" size="100%">D.R. Mani</style></author><author><style face="normal" font="default" size="100%">L.I. Shilling</style></author><author><style face="normal" font="default" size="100%">S.C. Hall</style></author><author><style face="normal" font="default" size="100%">B. McLean</style></author><author><style face="normal" font="default" size="100%">M. Albetolle</style></author><author><style face="normal" font="default" size="100%">S. Allen</style></author><author><style face="normal" font="default" size="100%">M. Burgess</style></author><author><style face="normal" font="default" size="100%">M.P. Cusack</style></author><author><style face="normal" font="default" size="100%">M Gosh</style></author><author><style face="normal" font="default" size="100%">V Hedrick</style></author><author><style face="normal" font="default" size="100%">J.M. Held</style></author><author><style face="normal" font="default" size="100%">H.D. Inerowicz</style></author><author><style face="normal" font="default" size="100%">A. Jackson</style></author><author><style face="normal" font="default" size="100%">H. Keshishian</style></author><author><style face="normal" font="default" size="100%">C.R. Kinsinger</style></author><author><style face="normal" font="default" size="100%">Lyssand, JS</style></author><author><style face="normal" font="default" size="100%">Makowski L</style></author><author><style face="normal" font="default" size="100%">Mesri M</style></author><author><style face="normal" font="default" size="100%">Rodriguez H</style></author><author><style face="normal" font="default" size="100%">Rudnick P</style></author><author><style face="normal" font="default" size="100%">Sadowski P</style></author><author><style face="normal" font="default" size="100%">Nell Sedransk</style></author><author><style face="normal" font="default" size="100%">Shaddox K</style></author><author><style face="normal" font="default" size="100%">Skates SJ</style></author><author><style face="normal" font="default" size="100%">Kuhn E</style></author><author><style face="normal" font="default" size="100%">Smith D</style></author><author><style face="normal" font="default" size="100%">Whiteaker, JR</style></author><author><style face="normal" font="default" size="100%">Whitwell C</style></author><author><style face="normal" font="default" size="100%">Zhang S</style></author><author><style face="normal" font="default" size="100%">Borchers CH</style></author><author><style face="normal" font="default" size="100%">Fisher SJ</style></author><author><style face="normal" font="default" size="100%">Gibson BW</style></author><author><style face="normal" font="default" size="100%">Liebler DC</style></author><author><style face="normal" font="default" size="100%">M.J. McCoss</style></author><author><style face="normal" font="default" size="100%">Neubert TA</style></author><author><style face="normal" font="default" size="100%">Paulovich AG</style></author><author><style face="normal" font="default" size="100%">Regnier FE</style></author><author><style face="normal" font="default" size="100%">Tempst, P</style></author><author><style face="normal" font="default" size="100%">Carr, SA</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma.</style></title><secondary-title><style face="normal" font="default" size="100%">Molecular Cell Proteomics</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">2357-74</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;There is an increasing need in biology and clinical medicine to robustly and reliably measure tens to hundreds of peptides and proteins in clinical and biological samples with high sensitivity, specificity, reproducibility, and repeatability. Previously, we demonstrated that LC-MRM-MS with isotope dilution has suitable performance for quantitative measurements of small numbers of relatively abundant proteins in human plasma and that the resulting assays can be transferred across laboratories while maintaining high reproducibility and quantitative precision. Here, we significantly extend that earlier work, demonstrating that 11 laboratories using 14 LC-MS systems can develop, determine analytical figures of merit, and apply highly multiplexed MRM-MS assays targeting 125 peptides derived from 27 cancer-relevant proteins and seven control proteins to precisely and reproducibly measure the analytes in human plasma. To ensure consistent generation of high quality data, we incorporated a system suitability protocol (SSP) into our experimental design. The SSP enabled real-time monitoring of LC-MRM-MS performance during assay development and implementation, facilitating early detection and correction of chromatographic and instrumental problems. Low to subnanogram/ml sensitivity for proteins in plasma was achieved by one-step immunoaffinity depletion of 14 abundant plasma proteins prior to analysis. Median intra- and interlaboratory reproducibility was &amp;lt;20%, sufficient for most biological studies and candidate protein biomarker verification. Digestion recovery of peptides was assessed and quantitative accuracy improved using heavy-isotope-labeled versions of the proteins as internal standards. Using the highly multiplexed assay, participating laboratories were able to precisely and reproducibly determine the levels of a series of analytes in blinded samples used to simulate an interlaboratory clinical study of patient samples. Our study further establishes that LC-MRM-MS using stable isotope dilution, with appropriate attention to analytical validation and appropriate quality control measures, enables sensitive, specific, reproducible, and quantitative measurements of proteins and peptides in complex biological matrices such as plasma.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">9</style></issue></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abbatiello, S.</style></author><author><style face="normal" font="default" size="100%">Feng, X.</style></author><author><style face="normal" font="default" size="100%">Sedransk, N.</style></author><author><style face="normal" font="default" size="100%">Mani, DR</style></author><author><style face="normal" font="default" size="100%">Schilling, B</style></author><author><style face="normal" font="default" size="100%">Maclean, B</style></author><author><style face="normal" font="default" size="100%">Zimmerman, LJ</style></author><author><style face="normal" font="default" size="100%">Cusack, MP</style></author><author><style face="normal" font="default" size="100%">Hall, SC</style></author><author><style face="normal" font="default" size="100%">Addona, T</style></author><author><style face="normal" font="default" size="100%">Allen, S</style></author><author><style face="normal" font="default" size="100%">Dodder, NG</style></author><author><style face="normal" font="default" size="100%">Ghosh, M</style></author><author><style face="normal" font="default" size="100%">Held, JM</style></author><author><style face="normal" font="default" size="100%">Hedrick, V</style></author><author><style face="normal" font="default" size="100%">Inerowicz, HD</style></author><author><style face="normal" font="default" size="100%">Jackson, A</style></author><author><style face="normal" font="default" size="100%">Keshishian, H</style></author><author><style face="normal" font="default" size="100%">Kim, JW</style></author><author><style face="normal" font="default" size="100%">Lyssand, JS</style></author><author><style face="normal" font="default" size="100%">Riley, CP</style></author><author><style face="normal" font="default" size="100%">Rudnick, P</style></author><author><style face="normal" font="default" size="100%">Sadowski, P</style></author><author><style face="normal" font="default" size="100%">Shaddox, K</style></author><author><style face="normal" font="default" size="100%">Smith, D</style></author><author><style face="normal" font="default" size="100%">Tomazela, D</style></author><author><style face="normal" font="default" size="100%">Wahlander, A</style></author><author><style face="normal" font="default" size="100%">Waldemarson, S</style></author><author><style face="normal" font="default" size="100%">Whitwell, CA</style></author><author><style face="normal" font="default" size="100%">You, J</style></author><author><style face="normal" font="default" size="100%">Zhang, S</style></author><author><style face="normal" font="default" size="100%">Kinsinger, CR</style></author><author><style face="normal" font="default" size="100%">Mesri, M</style></author><author><style face="normal" font="default" size="100%">Rodriguez, H</style></author><author><style face="normal" font="default" size="100%">Borchers, CH</style></author><author><style face="normal" font="default" size="100%">Buck, C</style></author><author><style face="normal" font="default" size="100%">Fisher, SJ</style></author><author><style face="normal" font="default" size="100%">Gibson, BW</style></author><author><style face="normal" font="default" size="100%">Liebler, D</style></author><author><style face="normal" font="default" size="100%">Maccoss, M</style></author><author><style face="normal" font="default" size="100%">Neubert, TA</style></author><author><style face="normal" font="default" size="100%">Paulovich, A</style></author><author><style face="normal" font="default" size="100%">Regnier, F</style></author><author><style face="normal" font="default" size="100%">Skates, SJ</style></author><author><style face="normal" font="default" size="100%">Tempst, P</style></author><author><style face="normal" font="default" size="100%">Wang, M</style></author><author><style face="normal" font="default" size="100%">Carr, SA</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Design, Implementation and Multisite Evaluation of a System Suitability Protocol for the Quantitative Assessment of Instrument Performance in Liquid Chromatography-Multiple Reaction Monitoring-MS (LC-MRM-MS)</style></title><secondary-title><style face="normal" font="default" size="100%">Molecular and Cellular Proteomics</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2013</style></year></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">2623-2639</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Multiple reaction monitoring (MRM) mass spectrometry coupled with stable isotope dilution (SID) and liquid chromatography (LC) is increasingly used in biological and clinical studies for precise and reproducible quantification of peptides and proteins in complex sample matrices. Robust LC-SID-MRM-MS-based assays that can be replicated across laboratories and ultimately in clinical laboratory settings require standardized protocols to demonstrate that the analysis platforms are performing adequately. We developed a system suitability protocol (SSP), which employs a predigested mixture of six proteins, to facilitate performance evaluation of LC-SID-MRM-MS instrument platforms, configured with nanoflow-LC systems interfaced to triple quadrupole mass spectrometers. The SSP was designed for use with low multiplex analyses as well as high multiplex approaches when software-driven scheduling of data acquisition is required. Performance was assessed by monitoring of a range of chromatographic and mass spectrometric metrics including peak width, chromatographic resolution, peak capacity, and the variability in peak area and analyte retention time (RT) stability. The SSP, which was evaluated in 11 laboratories on a total of 15 different instruments, enabled early diagnoses of LC and MS anomalies that indicated suboptimal LC-MRM-MS performance. The observed range in variation of each of the metrics scrutinized serves to define the criteria for optimized LC-SID-MRM-MS platforms for routine use, with pass/fail criteria for system suitability performance measures defined as peak area coefficient of variation &amp;lt;0.15, peak width coefficient of variation &amp;lt;0.15, standard deviation of RT &amp;lt;0.15 min (9 s), and the RT drift &amp;lt;0.5min (30 s). The deleterious effect of a marginally performing LC-SID-MRM-MS system on the limit of quantification (LOQ) in targeted quantitative assays illustrates the use and need for a SSP to establish robust and reliable system performance. Use of a SSP helps to ensure that analyte quantification measurements can be replicated with good precision within and across multiple laboratories and should facilitate more widespread use of MRM-MS technology by the basic biomedical and clinical laboratory research communities.&lt;/p&gt;
</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>47</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pauley, L.</style></author><author><style face="normal" font="default" size="100%">Kulikowich, J.</style></author><author><style face="normal" font="default" size="100%">Sedransk, N.</style></author><author><style face="normal" font="default" size="100%">Engel, R.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Studying the Reliability and Validity of Test Scores for Mathematical and Spatial Reasoning Tasks for Engineering Students</style></title><secondary-title><style face="normal" font="default" size="100%">Proceedings, American Society for Engineering Education</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2011</style></year></dates><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Stephan A. Carr</style></author><author><style face="normal" font="default" size="100%">Nell Sedransk.</style></author><author><style face="normal" font="default" size="100%">Henry Rodriguez</style></author><author><style face="normal" font="default" size="100%">Zivana Tezak</style></author><author><style face="normal" font="default" size="100%">Mehdi Mesri</style></author><author><style face="normal" font="default" size="100%">Daniel C. Liebler</style></author><author><style face="normal" font="default" size="100%">Susan J. Fisher</style></author><author><style face="normal" font="default" size="100%">Paul Tempst</style></author><author><style face="normal" font="default" size="100%">Tara Hiltke</style></author><author><style face="normal" font="default" size="100%">Larry G. Kessler</style></author><author><style face="normal" font="default" size="100%">Christopher R. Kinsinger</style></author><author><style face="normal" font="default" size="100%">Reena Philip</style></author><author><style face="normal" font="default" size="100%">David F. Ransohoff</style></author><author><style face="normal" font="default" size="100%">Steven J. Skates</style></author><author><style face="normal" font="default" size="100%">Fred E. Regnier</style></author><author><style face="normal" font="default" size="100%">N. Leigh Anderson</style></author><author><style face="normal" font="default" size="100%">Elizabeth Mansfield</style></author><author><style face="normal" font="default" size="100%">on behalf of the Workshop Participants</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analytical Validation of Proteomic-Based Multiplex Assays: A Workshop Report by the NCI-FDA Interagency Oncology Task Force on Molecular Diagnostics</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Clinical Chemistry</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2010</style></year></dates><volume><style face="normal" font="default" size="100%">56</style></volume><pages><style face="normal" font="default" size="100%">237-243</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Clinical proteomics has the potential to enable the early detection of cancer through the development of multiplex assays that can inform clinical decisions. However, there has been some uncertainty among translational researchers and developers as to the specific analytical measurement criteria needed to validate protein-based multiplex assays. To begin to address the causes of this uncertainty, a day-long workshop titled “Interagency Oncology Task Force Molecular Diagnostics Workshop” was held in which members of the proteomics and regulatory communities discussed many of the analytical evaluation issues that the field should address in development of protein-based multiplex assays for clinical use. This meeting report explores the issues raised at the workshop and details the recommendations that came out of the day’s discussions, such as a workshop summary discussing the analytical evaluation issues that specific proteomic technologies should address when seeking US Food and Drug Administration approval.&lt;/p&gt;
</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>47</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pauley, L.</style></author><author><style face="normal" font="default" size="100%">Kulikowich, J.M.</style></author><author><style face="normal" font="default" size="100%">Sedransk, N.</style></author><author><style face="normal" font="default" size="100%">Engel, R.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Constructing mathematical and spatial-reasoning measures for engineering students</style></title><secondary-title><style face="normal" font="default" size="100%">Proceedings, American Society for Engineering Education</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2010</style></year></dates><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Michael Last</style></author><author><style face="normal" font="default" size="100%">Gheorghe Luta</style></author><author><style face="normal" font="default" size="100%">Alex Orso</style></author><author><style face="normal" font="default" size="100%">Adam Porter</style></author><author><style face="normal" font="default" size="100%">Stan Young</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pooled ANOVA</style></title><secondary-title><style face="normal" font="default" size="100%">Computational Statistics &amp; Data Analysis</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2008</style></year></dates><volume><style face="normal" font="default" size="100%">52</style></volume><pages><style face="normal" font="default" size="100%">5215</style></pages><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">M.J. Bayarri</style></author><author><style face="normal" font="default" size="100%">J. Berger</style></author><author><style face="normal" font="default" size="100%">Garcia-Donato, G.</style></author><author><style face="normal" font="default" size="100%">Liu, F.</style></author><author><style face="normal" font="default" size="100%">R. Paulo</style></author><author><style face="normal" font="default" size="100%">Jerome Sacks</style></author><author><style face="normal" font="default" size="100%">Palomo, J.</style></author><author><style face="normal" font="default" size="100%">Walsh, D.</style></author><author><style face="normal" font="default" size="100%">J. Cafeo</style></author><author><style face="normal" font="default" size="100%">Parthasarathy, R.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Computer Model Validation with Functional Output</style></title><secondary-title><style face="normal" font="default" size="100%">Annals of  Statistics</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2007</style></year></dates><volume><style face="normal" font="default" size="100%">35</style></volume><pages><style face="normal" font="default" size="100%">1874-190</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><issue><style face="normal" font="default" size="100%">5</style></issue></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Murali Haran</style></author><author><style face="normal" font="default" size="100%">Alan Karr</style></author><author><style face="normal" font="default" size="100%">Michael Last</style></author><author><style face="normal" font="default" size="100%">Alessandro Orso</style></author><author><style face="normal" font="default" size="100%">Adam A. Porter</style></author><author><style face="normal" font="default" size="100%">Ashish Sanil</style></author><author><style face="normal" font="default" size="100%">Sandro Fouché</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Techniques for classifying executions of deployed software to support software engineering tasks</style></title><secondary-title><style face="normal" font="default" size="100%">IEEE TRANSACTIONS ON SOFTWARE ENGINEERING</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2007</style></year></dates><number><style face="normal" font="default" size="100%">5</style></number><volume><style face="normal" font="default" size="100%">33</style></volume><pages><style face="normal" font="default" size="100%">287-304</style></pages><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>10</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">A. F. Karr</style></author><author><style face="normal" font="default" size="100%">M. Haran</style></author><author><style face="normal" font="default" size="100%">A. A. Porter</style></author><author><style face="normal" font="default" size="100%">A. Orso</style></author><author><style face="normal" font="default" size="100%">A. P. Sanil</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Applying classification techniques to remotely-collected program execution data</style></title><secondary-title><style face="normal" font="default" size="100%">Proc. ACM SIGSOFT Symposium Foundations of Software Engineering 2005</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2005</style></year></dates><publisher><style face="normal" font="default" size="100%">ACM</style></publisher><pub-location><style face="normal" font="default" size="100%">New York</style></pub-location><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">R. Paulo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Default Priors for Gaussian Processes</style></title><secondary-title><style face="normal" font="default" size="100%">Annals of Statistics</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Computer model</style></keyword><keyword><style  face="normal" font="default" size="100%">frequentist coverage</style></keyword><keyword><style  face="normal" font="default" size="100%">Gaussian process</style></keyword><keyword><style  face="normal" font="default" size="100%">integrated likelihood</style></keyword><keyword><style  face="normal" font="default" size="100%">Jeffreys prior</style></keyword><keyword><style  face="normal" font="default" size="100%">posterior propriety</style></keyword><keyword><style  face="normal" font="default" size="100%">reference prior</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2005</style></year></dates><volume><style face="normal" font="default" size="100%">33</style></volume><pages><style face="normal" font="default" size="100%">556-582</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Motivated by the statistical evaluation of complex computer models, we deal with the issue of objective prior specification for the parameters of Gaussian processes. In particular, we derive the Jeffreys-rule, independence Jeffreys and reference priors for this situation, and prove that the resulting posterior distributions are proper under a quite general set of conditions. A proper flat prior strategy, based on maximum likelihood estimates, is also considered, and all priors are then compared on the grounds of the frequentist properties of the ensuing Bayesian procedures. Computational issues are also addressed in the paper, and we illustrate the proposed solutions by means of an example taken from the field of complex computer model validation.&lt;/p&gt;
</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>47</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">A. A. Porter</style></author><author><style face="normal" font="default" size="100%">A. F. Karr</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Distributed performance testing using statistical modeling</style></title><secondary-title><style face="normal" font="default" size="100%">ICSE 2005 Workshop on Advances in Model-Based Software Testing (A-MOST)</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2005</style></year></dates><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jeffrey D. Picka</style></author><author><style face="normal" font="default" size="100%">Chermakani, Karthik</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Random-walk-based estimates of transport properties in small specimens of composite materials</style></title><secondary-title><style face="normal" font="default" size="100%">Phys Rev E Stat Nonlin Soft Matter Phys</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Advanced Traveler Information Systems</style></keyword><keyword><style  face="normal" font="default" size="100%">random walks</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2003</style></year></dates><volume><style face="normal" font="default" size="100%">4</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;A method based on random walks is developed for estimating the dc conductance and similar transport properties in small specimens of composite materials. The method is valid over a much wider range of material structures than are asymptotic methods, and requires only that the internal structure of the material be known. The error in its estimates is limited primarily by CPU speed. It is found to work best for composites consisting of a bulk conducting phase and inclusions of lower conductivity.&lt;/p&gt;
</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bruce E Ankenman</style></author><author><style face="normal" font="default" size="100%">Hui Liu</style></author><author><style face="normal" font="default" size="100%">Alan F. Karr</style></author><author><style face="normal" font="default" size="100%">Jeffrey D. Picka</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Experimental designs for estimating a response surface and variance components</style></title><secondary-title><style face="normal" font="default" size="100%">Technometrics</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2002</style></year></dates><number><style face="normal" font="default" size="100%">1</style></number><volume><style face="normal" font="default" size="100%">44</style></volume><pages><style face="normal" font="default" size="100%">45-54</style></pages><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>10</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">M.J. Bayarri</style></author><author><style face="normal" font="default" size="100%">J. Berger</style></author><author><style face="normal" font="default" size="100%">D. Higdon</style></author><author><style face="normal" font="default" size="100%">M. Kottas</style></author><author><style face="normal" font="default" size="100%">R. Paulo</style></author><author><style face="normal" font="default" size="100%">J. Sacks</style></author><author><style face="normal" font="default" size="100%">J. Cafeo</style></author><author><style face="normal" font="default" size="100%">J. Cavendish</style></author><author><style face="normal" font="default" size="100%">C. Lin</style></author><author><style face="normal" font="default" size="100%">J. Tu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Framework for Validating Computer Models</style></title><secondary-title><style face="normal" font="default" size="100%">Workshop on Foundations for Modeling and Simulation</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2002</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2002</style></date></pub-dates></dates><publisher><style face="normal" font="default" size="100%">Society for Computer Simulation</style></publisher><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>5</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bar-Gera, Hillel</style></author><author><style face="normal" font="default" size="100%">Boyce, David</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Patriksson, Michael</style></author><author><style face="normal" font="default" size="100%">Labbé, Martine</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Origin-based Network Assignment</style></title><secondary-title><style face="normal" font="default" size="100%">Transportation Planning</style></secondary-title><tertiary-title><style face="normal" font="default" size="100%">Applied Optimization</style></tertiary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">network optimization</style></keyword><keyword><style  face="normal" font="default" size="100%">Origin-based traffic assignment</style></keyword><keyword><style  face="normal" font="default" size="100%">user equilibrium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2002</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1007/0-306-48220-7_1</style></url></web-urls></urls><publisher><style face="normal" font="default" size="100%">Springer US</style></publisher><volume><style face="normal" font="default" size="100%">64</style></volume><pages><style face="normal" font="default" size="100%">1-17</style></pages><isbn><style face="normal" font="default" size="100%">978-1-4020-0546-6</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>5</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bar-Gera, Hillel</style></author><author><style face="normal" font="default" size="100%">Boyce, David</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Patriksson, Michael</style></author><author><style face="normal" font="default" size="100%">Labbé, Martine</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Origin-based Network Assignment</style></title><secondary-title><style face="normal" font="default" size="100%">Transportation Planning</style></secondary-title><tertiary-title><style face="normal" font="default" size="100%">Applied Optimization</style></tertiary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">network optimization</style></keyword><keyword><style  face="normal" font="default" size="100%">Origin-based traffic assignment</style></keyword><keyword><style  face="normal" font="default" size="100%">user equilibrium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2002</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1007/0-306-48220-7_1</style></url></web-urls></urls><publisher><style face="normal" font="default" size="100%">Springer US</style></publisher><volume><style face="normal" font="default" size="100%">64</style></volume><pages><style face="normal" font="default" size="100%">1-17</style></pages><isbn><style face="normal" font="default" size="100%">978-1-4020-0546-6</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Most solution methods for the traffic assignment problem can be categorized as either link-based or route-based. Only a few attempts have followed the intermediate, origin-base dapproach. This paper describes the main concepts of a new, origin-based method for the static user equilibrium traffic assignment problem. Computational efficiency in time and memory makes this method suitable for large-scale networks of practical interest. Experimental results show that the new method is especially efficient in finding highly accurate solutions.&lt;/p&gt;
</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>32</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">R. Paulo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Problems on the Bayesian-Frequentist Interface</style></title></titles><dates><year><style  face="normal" font="default" size="100%">2002</style></year></dates><publisher><style face="normal" font="default" size="100%">Duke University</style></publisher><language><style face="normal" font="default" size="100%">eng</style></language><work-type><style face="normal" font="default" size="100%">masters</style></work-type></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jerome Sacks</style></author><author><style face="normal" font="default" size="100%">Nagui M. Rouphail</style></author><author><style face="normal" font="default" size="100%">B. Brian Park</style></author><author><style face="normal" font="default" size="100%">Piyushimita Thakuriah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Statistically-Based Validation of Computer Simulation Models in Traffic Operations and Management</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Transportation and Statistics</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Advanced traffic management systems</style></keyword><keyword><style  face="normal" font="default" size="100%">computer simulation</style></keyword><keyword><style  face="normal" font="default" size="100%">CORSIM</style></keyword><keyword><style  face="normal" font="default" size="100%">model validation</style></keyword><keyword><style  face="normal" font="default" size="100%">transportation policy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2002</style></year></dates><volume><style face="normal" font="default" size="100%">5</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The process of model validation is crucial for the use of computer simulation models in transportation policy, planning, and operations. This article lays out obstacles and issues involved in performing a validation. We describe a general process that emphasizes five essential ingredients for validation: context, data, uncertainty, feedback, and prediction. We use a test bed to generate specific (and general) questions as well as to give concrete form to answers and to the methods used in providing them. The traffic simulation model CORSIM serves as the test bed; we apply it to assess signal-timing plans on a street network of Chicago. The validation process applied in the test bed demonstrates how well CORSIM can reproduce field conditions, identifies flaws in the model, and shows how well CORSIM predicts performance under new (untried) signal conditions. We find that CORSIM, though imperfect, is effective with some restrictions in evaluating signal plans on urban networks.&lt;/p&gt;
</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Byungkyu Park</style></author><author><style face="normal" font="default" size="100%">Nagui M. Rouphail</style></author><author><style face="normal" font="default" size="100%">Jerome Sacks</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Assessment of Stochastic Signal Optimization Method Using Microsimulation</style></title><secondary-title><style face="normal" font="default" size="100%">Transportation Research Record</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2001</style></year></dates><volume><style face="normal" font="default" size="100%">1748</style></volume><pages><style face="normal" font="default" size="100%">40-45</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;A stochastic signal optimization method based on a genetic algorithm (GA-SOM) that interfaces with the microscopic simulation program CORSIM is assessed. A network in Chicago consisting of nine signalized intersections is used as an evaluation test bed. Taking CORSIM as the best representation of reality, the performance of the GA-SOM plan sets a ceiling on how good any (fixed) signal plan can be. An important aspect of this approach is its accommodations of variability. Also discussed is the robustness of an optimal plan under changes in demand. This benchmark is used to assess the best signal plan generated by TRANSYT-7F (T7F), Version 8.1, from among 12 reasonable strategies. The performance of the best T7F plan falls short of the benchmark on several counts, reflecting the need to account for variability in the highly stochastic system of traffic operations, which is not possible under the deterministic conditions intrinsic to T7F. As a sidelight, the performance of the GA-SOM plan within T7F is also computed and it is found to perform nearly as well as the optimum T7F plan.&lt;/p&gt;
</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>47</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Park, B.</style></author><author><style face="normal" font="default" size="100%">N. M. Rouphail</style></author><author><style face="normal" font="default" size="100%">J. Sacks</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Framework for Traffic Simulation Model Validation Procedure Using CORSIM as a Test-Bed</style></title><secondary-title><style face="normal" font="default" size="100%">2001 International Symposium on Advanced Highway Technology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2001</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2001</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>47</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">A. F. Karr</style></author><author><style face="normal" font="default" size="100%">N. Raghavan</style></author><author><style face="normal" font="default" size="100%">R. Bell</style></author><author><style face="normal" font="default" size="100%">M. Schonlau</style></author><author><style face="normal" font="default" size="100%">D. Pregibon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Defection detection: Using online activity profiles to predict ISP customer vulnerability</style></title><secondary-title><style face="normal" font="default" size="100%">Proceedings of the Sixth International Conference on Knowledge Discovery and Data Mining</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2000</style></year></dates><pages><style face="normal" font="default" size="100%">506?515</style></pages><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>10</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rouphail, N.</style></author><author><style face="normal" font="default" size="100%">Park, B.</style></author><author><style face="normal" font="default" size="100%">J. Sacks</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Direct Signal Timing Optimization: Strategy Development and Results</style></title><secondary-title><style face="normal" font="default" size="100%">XI Pan American Conference in Traffic and Transportation Engineering</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2000</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2000</style></date></pub-dates></dates><pages><style face="normal" font="default" size="100%">19-23</style></pages><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">A. F. Karr</style></author><author><style face="normal" font="default" size="100%">C.-M. Aldea</style></author><author><style face="normal" font="default" size="100%">J.D. Picka</style></author><author><style face="normal" font="default" size="100%">S. P. Shah</style></author><author><style face="normal" font="default" size="100%">S.S. Jaiswal</style></author><author><style face="normal" font="default" size="100%">T. Igusa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Experimental and statistical study of chloride permeability of cracked high strength concrete</style></title><secondary-title><style face="normal" font="default" size="100%">ASTM Cement, Concrete and Aggregates</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2000</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">2</style></number><volume><style face="normal" font="default" size="100%">22</style></volume><pages><style face="normal" font="default" size="100%">000-000</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Within any cast cylinder of concrete, the coarse aggregate will tend to be inhomogeneously distributed. This variability may arise as a result of segregation caused by gravity or as a result of the wall effect that is caused by the inability of the aggregate to penetrate the walls of the mold. Using methods from image analysis, stereology, and statistics, local estimates of aggregate inhomogeniety are defined that quantify phenomena that have been qualitatively described in the past. These methods involve modification of the two-dimensional images to prepare them for analysis, as well as simple diagnostic statistics for determining the presence of a wall effect. While the techniques presented herein are developed specifically for cast cylinders, they can be generalized to other cast or cored concrete specimens.&lt;/p&gt;
</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>47</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">A. F. Karr</style></author><author><style face="normal" font="default" size="100%">S. P. Shah</style></author><author><style face="normal" font="default" size="100%">S.S. Jaiswal</style></author><author><style face="normal" font="default" size="100%">B.E. Ankenman</style></author><author><style face="normal" font="default" size="100%">J.D. Picka</style></author><author><style face="normal" font="default" size="100%">T. Igusa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Impact of the interfacial transition zone on the chloride permeability of concrete</style></title><secondary-title><style face="normal" font="default" size="100%">Proc. 12th Engrg. Mechanics Conf</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2000</style></year></dates><pages><style face="normal" font="default" size="100%">1134-1137</style></pages><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kitamura, Ryuichi</style></author><author><style face="normal" font="default" size="100%">Chen, Cynthia</style></author><author><style face="normal" font="default" size="100%">Pendyala, Ram M.</style></author><author><style face="normal" font="default" size="100%">Narayanan, Ravi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Micro-simulation of daily activity-travel patterns for travel demand forecasting</style></title><secondary-title><style face="normal" font="default" size="100%">Transportation</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">daily activity-travel patterns</style></keyword><keyword><style  face="normal" font="default" size="100%">forecasting</style></keyword><keyword><style  face="normal" font="default" size="100%">micro-simulation</style></keyword><keyword><style  face="normal" font="default" size="100%">synthetic travel patterns</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2000</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1023/A%3A1005259324588</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">1</style></number><publisher><style face="normal" font="default" size="100%">Kluwer Academic Publishers</style></publisher><volume><style face="normal" font="default" size="100%">27</style></volume><pages><style face="normal" font="default" size="100%">25-51</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The development and initial validation results of a micro-simulator for the generation of daily activity-travel patterns are presented in this paper. The simulator assumes a sequential history and time-of-day dependent structure. Its components are developed based on a decomposition of a daily activity-travel pattern into components to which certain aspects of observed activity-travel behavior correspond, thus establishing a link between mathematical models and observational data. Each of the model components is relatively simple and is estimated using commonly adopted estimation methods and existing data sets. A computer code has been developed and daily travel patterns have been generated by Monte Carlo simulation. Study results show that individuals’ daily travel patterns can be synthesized in a practical manner by micro-simulation. Results of validation analyses suggest that properly representing rigidities in daily schedules is important in simulating daily travel patterns.&lt;/p&gt;
</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">A. F. Karr</style></author><author><style face="normal" font="default" size="100%">S.S. Jaiswal</style></author><author><style face="normal" font="default" size="100%">T. Igusa</style></author><author><style face="normal" font="default" size="100%">J.D. Picka</style></author><author><style face="normal" font="default" size="100%">S. P. Shah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Quantitative description of coarse aggregate volume fraction gradients</style></title><secondary-title><style face="normal" font="default" size="100%">Cement Concrete and Aggregates</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2000</style></year></dates><volume><style face="normal" font="default" size="100%">22</style></volume><pages><style face="normal" font="default" size="100%">151-159</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Within any cast cylinder of concrete, the coarse aggregate will tend to be inhomogeneously distributed. This variability may arise as a result of segregation caused by gravity or as a result of the wall effect that is caused by the inability of the aggregate to penetrate the walls of the mold. Using methods from image analysis, stereology, and statistics, local estimates of aggregate inhomogeniety are defined that quantify phenomena that have been qualitatively described in the past. These methods involve modification of the two-dimensional images to prepare them for analysis, as well as simple diagnostic statistics for determining the presence of a wall effect. While the techniques presented herein are developed specifically for cast cylinders, they can be generalized to other cast or cored concrete specimens.&lt;/p&gt;
</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">A. F. Karr</style></author><author><style face="normal" font="default" size="100%">S.S. Jaiswal</style></author><author><style face="normal" font="default" size="100%">J.D. Picka</style></author><author><style face="normal" font="default" size="100%">T. Igusa</style></author><author><style face="normal" font="default" size="100%">S. P. Shah</style></author><author><style face="normal" font="default" size="100%">B.E. Ankenman</style></author><author><style face="normal" font="default" size="100%">P. Styer</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Statistical studies of the conductivity of concrete using ASTM C1202?94</style></title><secondary-title><style face="normal" font="default" size="100%">Concrete Science and Engineering</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2000</style></year></dates><volume><style face="normal" font="default" size="100%">2</style></volume><pages><style face="normal" font="default" size="100%">97-105</style></pages><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>10</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Park, B.</style></author><author><style face="normal" font="default" size="100%">N. M. Rouphail</style></author><author><style face="normal" font="default" size="100%">J. Sacks</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Traffic Signal Offset Optimization Using Microscopic Simulation Program with Stochastic Process Model</style></title><secondary-title><style face="normal" font="default" size="100%">American Society of Civil Engineers</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2000</style></year></dates><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jeffrey D. Picka</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Variance Reducing Modifications for Estimators of Standardized Moments of Random Sets</style></title><secondary-title><style face="normal" font="default" size="100%">Advances in Applied Probability</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2000</style></year></dates><volume><style face="normal" font="default" size="100%">32</style></volume><pages><style face="normal" font="default" size="100%">682-700</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;In the statistical analysis of random sets, it is useful to have simple statistics that can be used to describe the realizations of these sets. The cumulants and several other standardized moments such as the correlation and second cumulant can be used for this purpose, but their estimators can be excessively variable if the most straightforward estimation strategy is used. Through exploitation of similarities between this estimation problem and a similar one for a point process statistic, two modifications are proposed. Analytical results concerning the effects of these modifications are found through use of a specialized asymptotic regime. Simulation results establish that the modifications are highly effective at reducing estimator standard deviations for Boolean models. The results suggest that the reductions in variance result from a balanced use of information in the estimation of the first and second moments, through eliminating the use of observations that are not used in second moment estimation.&lt;/p&gt;
</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>47</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">A. F. Karr</style></author><author><style face="normal" font="default" size="100%">C.-M. Aldea</style></author><author><style face="normal" font="default" size="100%">S.S. Jaiswal</style></author><author><style face="normal" font="default" size="100%">B.E. Ankenman</style></author><author><style face="normal" font="default" size="100%">J.D. Picka</style></author><author><style face="normal" font="default" size="100%">T. Igusa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Water permeability of cracked concrete</style></title><secondary-title><style face="normal" font="default" size="100%">Proc. 12th Engrg. Mechanics Conf</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2000</style></year></dates><pages><style face="normal" font="default" size="100%">1158?1162</style></pages><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>5</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Susan Paddock</style></author><author><style face="normal" font="default" size="100%">Michael West</style></author><author><style face="normal" font="default" size="100%">S. Stanley Young</style></author><author><style face="normal" font="default" size="100%">M. Clyde</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Bayesian Mixture Models in Exploration of Structure-Activity Relationships in Drug Design</style></title><secondary-title><style face="normal" font="default" size="100%">Statistics in Science and Technology: Case Studies 4</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">1998</style></year></dates><publisher><style face="normal" font="default" size="100%">Springer-Verlag</style></publisher><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>5</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Xie, Minge</style></author><author><style face="normal" font="default" size="100%">Simpson, Douglas</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Nychka, Douglas</style></author><author><style face="normal" font="default" size="100%">Piegorsch, Walter W.</style></author><author><style face="normal" font="default" size="100%">Lawrence H. Cox</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Categorical Exposure-Response Regression Analysis of Toxicology Experiments</style></title><secondary-title><style face="normal" font="default" size="100%">Case Studies in Environmental Statistics</style></secondary-title><tertiary-title><style face="normal" font="default" size="100%">Lecture Notes in Statistics</style></tertiary-title></titles><dates><year><style  face="normal" font="default" size="100%">1998</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1007/978-1-4612-2226-2_7</style></url></web-urls></urls><publisher><style face="normal" font="default" size="100%">Springer US</style></publisher><volume><style face="normal" font="default" size="100%">132</style></volume><pages><style face="normal" font="default" size="100%">121-141</style></pages><isbn><style face="normal" font="default" size="100%">978-0-387-98478-0</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;In the mid-1980s, an accident at the Union Carbide pesticides plant in Bhopal, India released the toxic gas methylisocyanate (MIC) in that densely populated region, killing more than 4000 people and injuring 500,000 others. Even today, many people in Bhopal are affected by illnesses related to that earlier exposure. This notorious industrial disaster not only forced scientists to pay greater attention to identifying and handling of hazardous chemicals but also prompted greater awareness of those common industrial products that contain hazard pollutants.&lt;/p&gt;
</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>47</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Todd L. Graves</style></author><author><style face="normal" font="default" size="100%">Harrold, Mary Jean</style></author><author><style face="normal" font="default" size="100%">Kim, Jung-Min</style></author><author><style face="normal" font="default" size="100%">Adam Porter</style></author><author><style face="normal" font="default" size="100%">Rothermel, Gregg</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">An Empirical Study of Regression Test Selection Techniques</style></title><secondary-title><style face="normal" font="default" size="100%">Proceedings of the 20th International Conference on Software Engineering</style></secondary-title><tertiary-title><style face="normal" font="default" size="100%">ICSE ’98</style></tertiary-title></titles><dates><year><style  face="normal" font="default" size="100%">1998</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://dl.acm.org/citation.cfm?id=302163.302182</style></url></web-urls></urls><publisher><style face="normal" font="default" size="100%">IEEE Computer Society</style></publisher><pub-location><style face="normal" font="default" size="100%">Washington, DC, USA</style></pub-location><pages><style face="normal" font="default" size="100%">188–197</style></pages><isbn><style face="normal" font="default" size="100%">0-8186-8368-6</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>5</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lawrence H. Cox</style></author><author><style face="normal" font="default" size="100%">Nychka, Douglas</style></author><author><style face="normal" font="default" size="100%">Piegorsch, Walter W.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Introduction: Problems in Environmental Monitoring and Assessment</style></title><secondary-title><style face="normal" font="default" size="100%">Case Studies in Environmental Statistics</style></secondary-title><tertiary-title><style face="normal" font="default" size="100%">Lecture Notes in Statistics</style></tertiary-title></titles><dates><year><style  face="normal" font="default" size="100%">1998</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1007/978-1-4612-2226-2_1</style></url></web-urls></urls><publisher><style face="normal" font="default" size="100%">Springer US</style></publisher><volume><style face="normal" font="default" size="100%">132</style></volume><pages><style face="normal" font="default" size="100%">1-4</style></pages><isbn><style face="normal" font="default" size="100%">978-0-387-98478-0</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The need for innovative statistical methods for modern environmental assessment is undisputed. The case studies in this book are a sampling of the broad sweep of statistical applications available in the environmental sciences, targeted to environmental monitoring and assessment. A unique feature of the applications presented here is that they are not isolated projects but were, instead, fostered under a long-term collaborative association between the U.S. Environmental Protection Agency (EPA) and the National Institute of Statistical Sciences (NISS). This institutional support resulted in a strong interdisciplinary component to the research, and common threads of statistical methodology and data analysis principles are seen across all of the projects. The case studies necessarily are detailed and technical and so this introductory chapter will give an overview of what follows and emphasize common themes that tie the projects together. Research, by its very nature, does not follow a direct path and depends on past results for the next step. This process is enriched through the collaboration of statisticians with other scientists.&lt;/p&gt;
</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>5</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lawrence H. Cox</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Nychka, Douglas</style></author><author><style face="normal" font="default" size="100%">Piegorsch, Walter W.</style></author><author><style face="normal" font="default" size="100%">Lawrence H. Cox</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Workshop: Statistical Methods for Combining Environmental Information</style></title><secondary-title><style face="normal" font="default" size="100%">Case Studies in Environmental Statistics</style></secondary-title><tertiary-title><style face="normal" font="default" size="100%">Lecture Notes in Statistics</style></tertiary-title></titles><dates><year><style  face="normal" font="default" size="100%">1998</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1007/978-1-4612-2226-2_8</style></url></web-urls></urls><publisher><style face="normal" font="default" size="100%">Springer US</style></publisher><volume><style face="normal" font="default" size="100%">132</style></volume><pages><style face="normal" font="default" size="100%">143-158</style></pages><isbn><style face="normal" font="default" size="100%">978-0-387-98478-0</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Primary objectives of the NISS-USEPA cooperative research agreement were to identify important environmental problems to which statistical science could contribute, to perform interdisciplinary research on these problems and stimulate related research and problem identification within the broader statistical community, to assess important examples and areas of environmetric research, and to identify new research problems and directions. To provide a forum for identifying and examining new research and problem areas, a NISS-USEPA workshop series was established within the cooperative research program.&lt;/p&gt;
</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>5</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nobile, Agostino</style></author><author><style face="normal" font="default" size="100%">Bhat, Chandra R.</style></author><author><style face="normal" font="default" size="100%">Pas, Eric I.</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Gatsonis, Constantine</style></author><author><style face="normal" font="default" size="100%">Hodges, JamesS.</style></author><author><style face="normal" font="default" size="100%">Kass, RobertE.</style></author><author><style face="normal" font="default" size="100%">McCulloch, Robert</style></author><author><style face="normal" font="default" size="100%">Rossi, Peter</style></author><author><style face="normal" font="default" size="100%">Singpurwalla, NozerD.</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">A Random-Effects Multinomial Probit Model of Car Ownership Choice</style></title><secondary-title><style face="normal" font="default" size="100%">Case Studies in Bayesian Statistics</style></secondary-title><tertiary-title><style face="normal" font="default" size="100%">Lecture Notes in Statistics</style></tertiary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">car ownership</style></keyword><keyword><style  face="normal" font="default" size="100%">longitudinal data</style></keyword><keyword><style  face="normal" font="default" size="100%">Multinomial probit model</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">1997</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1007/978-1-4612-2290-3_13</style></url></web-urls></urls><publisher><style face="normal" font="default" size="100%">Springer New York</style></publisher><volume><style face="normal" font="default" size="100%">121</style></volume><pages><style face="normal" font="default" size="100%">419-434</style></pages><isbn><style face="normal" font="default" size="100%">978-0-387-94990-1</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The number of cars in a household has an important effect on its travel behavior (e.g., choice of number of trips, mode to work and non-work destinations), hence car ownership modeling is an essential component of any travel demand forecasting effort. In this paper we report on a random effects multinomial probit model of car ownership level, estimated using longitudinal data collected in the Netherlands. A Bayesian approach is taken and the model is estimated by means of a modification of the Gibbs sampling with data augmentation algorithm considered by McCulloch and Rossi (1994). The modification consists in performing, after each Gibbs sampling cycle, a Metropolis step along a direction of constant likelihood. An examination of the simulation output illustrates the improved performance of the resulting sampler.&lt;/p&gt;
</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>47</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">A. F. Karr</style></author><author><style face="normal" font="default" size="100%">A. A. Porter</style></author><author><style face="normal" font="default" size="100%">L. G. Votta</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">An empirical exploration of code evolution</style></title><secondary-title><style face="normal" font="default" size="100%">Proceedings of the InternationalWorkshop on Empirical Studies of Software Maintenance</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">1996</style></year></dates><language><style face="normal" font="default" size="100%">eng</style></language></record></records></xml>