Research Projects


The National Institute of Statistical Sciences (NISS) established a Cross-Sector Research in Residence Program in partnership with the National Agricultural Statistics Service (NASS), the survey and estimation arm of the U.S. Department of Agriculture. This new collaborative venture by NISS and the... more


Senior Researcher:
NISS has joined the Clinical Proteomic Technologies for Cancer research initiative that focuses on technologies for cancer biomarker discovery. The overall goal is to foster the building of an integrated foundation of proteomic technologies, data, reagents and reference materials, and analysis... more

Clinical Medical Research

Senior Researcher:
One of the factors the Federal Drug Administration (FDA) looks for when evaluating a drug is the potential for that drug to induce a cardiac arrhythmia. When a drug is administered to a patient, some of them can interfere with the normal electrical signals of the heart. In a normal heartbeat, the... more


Senior Researcher:
NISS conducted research in data confidentiality, data quality, and data integration. Prototypes were built which could scale to operate on large sets of Federally held data. Researchers partnered with several large Federal Government statistical agencies. This topic was of particular importance... more


Senior Researcher:
The goal of this project is to reconcile two methods for modeling change in social networks over time: a class of statistical models and intelligent agent models. The research contrasts the roperties of these two approaches, exploring what qualitative dynamic behaviors in social networks are... more

Disease Surveillance

Senior Researcher:
Syndromic surveillance uses syndrome (a specific collection of clinical symptoms) data to monitor for indications of a potential or incipient disease outbreak. Other advanced surveillance systems have been implemented globally for early detection of infectious disease outbreaks and bioterrorist... more


This white paper is intended to lay out for the National Center for Education Statistics (NCES) available algorithms and technology solutions for secure, principled statistical analysis of distributed data, as well as to identify gaps in our current understanding. For concreteness, the following... more

Education Statistics

The National Center for Education Statistics (NCES) charged the National Institute of Statistical Sciences (NISS) with convening a panel of technical experts to consider the issues of accounting for missing data in educational surveys. In particular, the panel was asked to address the following... more

Environmental Science

Senior Researcher:
The Environmental Protection Agency and scientists from several universities across the United States and Canada worked on network design for environmental monitoring; space-time models, data fusion, health and pharmacokinetics; risk assesment of toxicants; and data representation and reporting.


Senior Researcher:
Emerging OMICS technologies such as microarray and highthroughput screening have been adopted across a broad spectrum of applications as these technologies are capable of simultaneous measurements of very large numbers of channels. Thus they enable rapid experimental turnaround with an accompanying... more

Software Development

Senior Researcher:
The goal was to design, implement and evaluate light weight instrumentation for software testing and profiling. The underlying concept was that different instances (users' copies) of the software are instrumented to collect information differently bu lightly so that performance is not impaired.... more

Survey Research

Senior Researcher:
NISS and Duke University are collaborating on the Triangle Census Research Network (TCRN), one of eight research nodes that are working on the National Census Research Network (NCRN). NISS and Duke are looking at ways to improve how federal statistical (“FedStats”) agencies disseminate data to the... more


Senior Researcher:
The Chicago Department of Transportation (CDOT) implemented NISS-developed strategies for operation of traffic signals on the near North side of Chicago. A team consisting of NISS, North Carolina State University, the University of Illinois at Chicago, and CDOT developed prediction models using... more